Insights: Publications Cellular Immunotherapy to Overcome Temozolomide Induced T Cell Exhaustion in Glioblastoma
Neuro-Oncology 21, Issue Supplement 6: vi120
We have previously demonstrated that standard dose (SD) temozolomide results in T cell exhaustion in glioblastoma. In this study, we hypothesized that cellular immunotherapies will prevent T cell exhaustion. We tested temozolomide treatment with adoptive T cell transfer alone, dendritic cell (DC) vaccines alone and T cell transfer in combination with DC vaccines.
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